Assay Detail
Binding
CHEMBL1118599
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Inhibition of electric eel AChE
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of 2,4-disubstituted pyrimidines as cholinesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.65 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL32823 | — | — | 1 | 8.74 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.76 |
| CHEMBL1086014 | — | — | 1 | 6.48 |
| CHEMBL1082977 | — | — | 1 | 6.41 |
| CHEMBL1085781 | — | — | 1 | 6.30 |
| CHEMBL1084808 | — | — | 1 | 6.25 |
| CHEMBL1085505 | — | — | 1 | 5.32 |
| CHEMBL1084210 | — | — | 1 | 5.24 |
| CHEMBL1082981 | — | — | 1 | 5.10 |
| CHEMBL1085780 | — | — | 1 | 5.01 |
| CHEMBL1082978 | — | — | 1 | 4.92 |
| CHEMBL1082980 | — | — | 1 | 4.84 |
| CHEMBL1084212 | — | — | 1 | 4.81 |
| CHEMBL1084211 | — | — | 1 | 4.80 |
| CHEMBL1084213 | — | — | 1 | 4.75 |
| CHEMBL1082979 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL32823 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL95 | TACRINE | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL1086014 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL1082977 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL1085781 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1084808 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL1085505 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL1084210 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL1082981 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL1085780 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL1082978 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1082980 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL1084212 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL1084211 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL1084213 | — | IC50 | = | 17600.0 | nM | 4.75 |
| CHEMBL1082979 | — | IC50 | = | 25000.0 | nM | 4.60 |