Assay Detail
Binding
CHEMBL1118889
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Inhibition of MMP2
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Orally bioavailable dual MMP-1/MMP-14 sparing, MMP-13 selective alpha-sulfone hydroxamates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 7.07 | 9.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1082381 | — | — | 1 | 9.48 |
| CHEMBL1084221 | — | — | 1 | 8.70 |
| CHEMBL1084509 | — | — | 1 | 8.43 |
| CHEMBL1083932 | — | — | 1 | 8.36 |
| CHEMBL1084510 | — | — | 1 | 8.28 |
| CHEMBL1084218 | — | — | 1 | 8.27 |
| CHEMBL1084238 | — | — | 1 | 7.92 |
| CHEMBL1084208 | — | — | 1 | 7.74 |
| CHEMBL1082966 | — | — | 1 | 7.68 |
| CHEMBL1085602 | — | — | 1 | 7.63 |
| CHEMBL1083931 | — | — | 1 | 7.49 |
| CHEMBL1084209 | — | — | 1 | 7.46 |
| CHEMBL1083907 | — | — | 1 | 7.40 |
| CHEMBL1084206 | — | — | 1 | 7.31 |
| CHEMBL1083322 | — | — | 1 | 7.16 |
| CHEMBL1083625 | — | — | 1 | 7.09 |
| CHEMBL1083906 | — | — | 1 | 7.06 |
| CHEMBL1084207 | — | — | 1 | 6.48 |
| CHEMBL1083908 | — | — | 1 | 6.43 |
| CHEMBL1082370 | — | — | 1 | 6.30 |
| CHEMBL1082371 | — | — | 1 | 6.30 |
| CHEMBL1083626 | — | — | 1 | 6.16 |
| CHEMBL1085264 | — | — | 1 | 6.10 |
| CHEMBL1083007 | — | — | 1 | 6.05 |
| CHEMBL1084217 | — | — | 1 | 5.85 |
| CHEMBL1085263 | — | — | 1 | 5.76 |
| CHEMBL1083321 | — | — | 1 | 5.51 |
| CHEMBL1084220 | — | — | 1 | 5.43 |
| CHEMBL1085988 | — | — | 1 | 5.27 |
| CHEMBL1085748 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1082381 | — | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL1084221 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1084509 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL1083932 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL1084510 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL1084218 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL1084238 | — | IC50 | = | 12.1 | nM | 7.92 |
| CHEMBL1084208 | — | IC50 | = | 18.4 | nM | 7.74 |
| CHEMBL1082966 | — | IC50 | = | 21.1 | nM | 7.68 |
| CHEMBL1085602 | — | IC50 | = | 23.5 | nM | 7.63 |
| CHEMBL1083931 | — | IC50 | = | 32.6 | nM | 7.49 |
| CHEMBL1084209 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL1083907 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1084206 | — | IC50 | = | 48.5 | nM | 7.31 |
| CHEMBL1083322 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1083625 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL1083906 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL1084207 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL1083908 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL1082370 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1082371 | — | IC50 | = | 505.0 | nM | 6.30 |
| CHEMBL1083626 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL1085264 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1083007 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL1084217 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1085263 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL1083321 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL1084220 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL1085988 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL1085748 | — | IC50 | > | 10000.0 | nM | - |