Assay Detail
Binding
CHEMBL1119329
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Inhibition of bovine spleen cathepsin L
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Tissue | Spleen |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
On-bead screening of a combinatorial fumaric acid derived peptide library yields antiplasmodial cysteine protease inhibitors with unusual peptide sequences.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 4.49 | 4.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1086438 | — | — | 1 | 4.68 |
| CHEMBL1086435 | — | — | 1 | 4.51 |
| CHEMBL1086436 | — | — | 1 | 4.47 |
| CHEMBL1086429 | — | — | 1 | 4.46 |
| CHEMBL1086432 | — | — | 1 | 4.43 |
| CHEMBL1086437 | — | — | 1 | 4.40 |
| CHEMBL1086431 | — | — | 1 | - |
| CHEMBL1086434 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1086438 | — | Ki | = | 20800.0 | nM | 4.68 |
| CHEMBL1086435 | — | Ki | = | 30700.0 | nM | 4.51 |
| CHEMBL1086436 | — | Ki | = | 33600.0 | nM | 4.47 |
| CHEMBL1086429 | — | Ki | = | 34800.0 | nM | 4.46 |
| CHEMBL1086432 | — | Ki | = | 37500.0 | nM | 4.43 |
| CHEMBL1086437 | — | Ki | = | 40000.0 | nM | 4.40 |
| CHEMBL1086431 | — | Ki | - | — | - | |
| CHEMBL1086434 | — | Ki | - | — | - |