Assay Detail

CHEMBL1119655

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Functional

Inhibition of capillary tube formation in HUVEC

ChEMBL ↗

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Target

HUVEC (CHEMBL613979) ↗

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Primary target HUVEC

CHEMBL613979

Anchored from Assay target.

Protein identity HUVEC

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	HUVEC
Confidence	1 — Organism
Curated By	Autocuration

Target

HUVEC (CHEMBL613979) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

8-THP-DHI analogs as potent Type I dual TIE-2/VEGF-R2 receptor tyrosine kinase inhibitors.

Hudkins RL, Zulli AL, Underiner TL, Angeles TS, Aimone LD, Meyer SL, Pauletti D, Chang H, Fedorov EV, Almo SC, Fedorov AA, Ruggeri BA.
Bioorg Med Chem Lett (2010) 20 : 3356 -3360
PubMed 20430619 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	2	8.96	9.22

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1082829	—	—	1	9.22
CHEMBL1084337	—	—	1	8.70

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1082829	—	EC50	=	0.6	nM	9.22
CHEMBL1084337	—	EC50	=	2.0	nM	8.70