Assay Detail
Binding
CHEMBL1119677
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Inhibition of DPP4
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
(2S,4S)-1-[2-(1,1-dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.48 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL385517 | SAXAGLIPTIN ANHYDROUS | 4.0 | 1 | 8.47 |
| CHEMBL1082462 | DBPR-108 | 3.0 | 1 | 7.82 |
| CHEMBL201644 | — | — | 1 | 7.82 |
| CHEMBL1082996 | — | — | 1 | 7.82 |
| CHEMBL1085075 | — | — | 1 | 7.75 |
| CHEMBL1085306 | — | — | 1 | 7.72 |
| CHEMBL1085552 | — | — | 1 | 7.72 |
| CHEMBL1085333 | — | — | 1 | 7.70 |
| CHEMBL1085595 | — | — | 1 | 7.62 |
| CHEMBL1086039 | — | — | 1 | 7.62 |
| CHEMBL1085332 | — | — | 1 | 7.58 |
| CHEMBL1085074 | — | — | 1 | 7.57 |
| CHEMBL1085580 | — | — | 1 | 7.57 |
| CHEMBL1085305 | — | — | 1 | 7.57 |
| CHEMBL1084972 | — | — | 1 | 7.54 |
| CHEMBL1422 | SITAGLIPTIN | 4.0 | 1 | 7.52 |
| CHEMBL1082463 | — | — | 1 | 7.52 |
| CHEMBL1085579 | — | — | 1 | 7.50 |
| CHEMBL1082465 | — | — | 1 | 7.41 |
| CHEMBL1082464 | — | — | 1 | 7.30 |
| CHEMBL142703 | VILDAGLIPTIN | 4.0 | 1 | 7.29 |
| CHEMBL1085597 | — | — | 1 | 7.20 |
| CHEMBL1084601 | — | — | 1 | 7.18 |
| CHEMBL1082997 | — | — | 1 | 7.15 |
| CHEMBL1085596 | — | — | 1 | 7.03 |
| CHEMBL217198 | — | — | 1 | 6.94 |
| CHEMBL1085598 | — | — | 1 | 6.80 |
| CHEMBL1086502 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL385517 | SAXAGLIPTIN ANHYDROUS | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL1082462 | DBPR-108 | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL201644 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1082996 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1085075 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1085306 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1085552 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1085333 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1085595 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1086039 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1085332 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL1085074 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1085580 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1085305 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1084972 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL1422 | SITAGLIPTIN | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1082463 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1085579 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL1082465 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL1082464 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL142703 | VILDAGLIPTIN | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL1085597 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL1084601 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL1082997 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL1085596 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL217198 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL1085598 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1086502 | — | IC50 | = | 180.0 | nM | 6.75 |