Assay Detail
Binding
CHEMBL1119686
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Inhibition of DPP4 in presence of 50% human serum
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
(2S,4S)-1-[2-(1,1-dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.66 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1082462 | DBPR-108 | 3.0 | 1 | 8.30 |
| CHEMBL1085333 | — | — | 1 | 7.89 |
| CHEMBL1085074 | — | — | 1 | 7.85 |
| CHEMBL1085595 | — | — | 1 | 7.82 |
| CHEMBL142703 | VILDAGLIPTIN | 4.0 | 1 | 7.77 |
| CHEMBL1422 | SITAGLIPTIN | 4.0 | 1 | 7.75 |
| CHEMBL1085552 | — | — | 1 | 7.75 |
| CHEMBL1085306 | — | — | 1 | 7.72 |
| CHEMBL1082463 | — | — | 1 | 7.68 |
| CHEMBL1082996 | — | — | 1 | 6.07 |
| CHEMBL1085579 | — | — | 1 | - |
| CHEMBL1085580 | — | — | 1 | - |
| CHEMBL1085075 | — | — | 1 | - |
| CHEMBL1084972 | — | — | 1 | - |
| CHEMBL1085305 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1082462 | DBPR-108 | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1085333 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1085074 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1085595 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL142703 | VILDAGLIPTIN | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1422 | SITAGLIPTIN | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1085552 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1085306 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1082463 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1082996 | — | IC50 | = | 847.0 | nM | 6.07 |
| CHEMBL1085579 | — | IC50 | - | — | - | |
| CHEMBL1085580 | — | IC50 | - | — | - | |
| CHEMBL1085075 | — | IC50 | - | — | - | |
| CHEMBL1084972 | — | IC50 | - | — | - | |
| CHEMBL1085305 | — | IC50 | - | — | - |