Assay Detail
Binding
CHEMBL1120081
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Inhibition of ROCK2 by luciferase based ATP detection assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: part 3, aryl substituted pyrrolidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.90 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1083747 | — | — | 1 | 8.70 |
| CHEMBL1084051 | — | — | 1 | 8.40 |
| CHEMBL1082821 | — | — | 1 | 8.40 |
| CHEMBL1084653 | — | — | 1 | 8.40 |
| CHEMBL1083276 | — | — | 1 | 8.40 |
| CHEMBL1083748 | — | — | 1 | 8.40 |
| CHEMBL1083749 | — | — | 1 | 8.30 |
| CHEMBL1082819 | — | — | 1 | 8.22 |
| CHEMBL1084324 | — | — | 1 | 8.22 |
| CHEMBL1084597 | — | — | 1 | 8.22 |
| CHEMBL1085773 | — | — | 1 | 8.22 |
| CHEMBL1084800 | — | — | 1 | 8.15 |
| CHEMBL1084104 | — | — | 1 | 8.10 |
| CHEMBL1083799 | — | — | 1 | 8.10 |
| CHEMBL1084110 | — | — | 1 | 8.05 |
| CHEMBL1082820 | — | — | 1 | 7.96 |
| CHEMBL1084554 | — | — | 1 | 7.96 |
| CHEMBL1084892 | — | — | 1 | 7.92 |
| CHEMBL1083800 | — | — | 1 | 7.85 |
| CHEMBL1083115 | — | — | 1 | 7.82 |
| CHEMBL1084105 | — | — | 1 | 7.58 |
| CHEMBL1085082 | — | — | 1 | 7.55 |
| CHEMBL1083113 | — | — | 1 | 7.51 |
| CHEMBL1085341 | — | — | 1 | 7.33 |
| CHEMBL1085083 | — | — | 1 | 7.17 |
| CHEMBL1083114 | — | — | 1 | 6.92 |
| CHEMBL1085342 | — | — | 1 | 6.64 |
| CHEMBL1084323 | — | — | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1083747 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1084051 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1082821 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1084653 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1083276 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1083748 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1083749 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1082819 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1084324 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1084597 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1085773 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1084800 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1084104 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1083799 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1084110 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1082820 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1084554 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1084892 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1083800 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1083115 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1084105 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL1085082 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1083113 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL1085341 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL1085083 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL1083114 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1085342 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1084323 | — | IC50 | = | 240.0 | nM | 6.62 |