Assay Detail
Binding
CHEMBL1120109
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Inhibition of DPP4
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of azobicyclo[3.3.0] octane derivatives as dipeptidyl peptidase 4 inhibitors for the treatment of type 2 diabetes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.57 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL142703 | VILDAGLIPTIN | 4.0 | 1 | 8.05 |
| CHEMBL1085269 | — | — | 1 | 8.05 |
| CHEMBL1083287 | — | — | 1 | 7.89 |
| CHEMBL1083588 | — | — | 1 | 7.89 |
| CHEMBL1083032 | — | — | 1 | 7.85 |
| CHEMBL1083031 | — | — | 1 | 7.62 |
| CHEMBL1082707 | — | — | 1 | 7.41 |
| CHEMBL1082716 | — | — | 1 | 7.30 |
| CHEMBL1082708 | — | — | 1 | 7.16 |
| CHEMBL1086466 | — | — | 1 | 7.08 |
| CHEMBL1085522 | — | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL142703 | VILDAGLIPTIN | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1085269 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1083287 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1083588 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1083032 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1083031 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1082707 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL1082716 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1082708 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL1086466 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL1085522 | — | IC50 | = | 120.0 | nM | 6.92 |