Assay Detail
Binding
CHEMBL1120545
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Binding affinity to single-strand oligonucleotide Pu39 assessed as formation of G-quadruplex complex after 3 mins by PCR stop assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Turning off transcription of the bcl-2 gene by stabilizing the bcl-2 promoter quadruplex with quindoline derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.05 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL491432 | — | — | 1 | 5.96 |
| CHEMBL1083312 | — | — | 1 | 4.13 |
| CHEMBL222885 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL491432 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL1083312 | — | IC50 | = | 74400.0 | nM | 4.13 |
| CHEMBL222885 | — | IC50 | > | 100000.0 | nM | - |