Assay Detail
Binding
CHEMBL1120548
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to Bcl-2 promoter duplex DNA by surface plasmon resonance assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Turning off transcription of the bcl-2 gene by stabilizing the bcl-2 promoter quadruplex with quindoline derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 6.12 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL491432 | — | — | 1 | 6.57 |
| CHEMBL1083312 | — | — | 1 | 6.32 |
| CHEMBL222885 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL491432 | — | Kd | = | 269.0 | nM | 6.57 |
| CHEMBL1083312 | — | Kd | = | 482.0 | nM | 6.32 |
| CHEMBL222885 | — | Kd | = | 3380.0 | nM | 5.47 |