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Assay Detail

CHEMBL1120571

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [125I]echistatin from integrin alphaVbeta3 in human NCI-H1975 cells after 3 hrs by gamma counting
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type NCI-H1975
Confidence 7 — Homologous single protein target
Curated By Autocuration

Target

Integrin alpha-V/beta-3 (CHEMBL1907598)
Type PROTEIN COMPLEX
Organism Homo sapiens

Publication

Emerging targets in osteoporosis disease modification.
Allen JG, Fotsch C, Babij P.
J Med Chem (2010) 53 : 4332 -4353
PubMed 20218623 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 10.52 10.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL378530 1 10.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL378530 IC50 = 0.03 nM 10.52