Assay Detail
Binding
CHEMBL1120643
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mushroom tyrosinase preincubated for 5 mins before addition of L-DOPA measured after 10 mins
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Agaricus bisporus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of oxadiazole and triazolothiadiazole derivatives as tyrosinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.78 | 6.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1082311 | — | — | 1 | 6.06 |
| CHEMBL1085991 | — | — | 1 | 6.01 |
| CHEMBL1085993 | — | — | 1 | 5.88 |
| CHEMBL1085992 | — | — | 1 | 5.87 |
| CHEMBL1085994 | — | — | 1 | 5.83 |
| CHEMBL287556 | KOJIC ACID | — | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1082311 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL1085991 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL1085993 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL1085992 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL1085994 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL287556 | KOJIC ACID | IC50 | = | 9180.0 | nM | 5.04 |