Assay Detail
Binding
CHEMBL1120946
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LFA1-mediated adhesion of human T cells to ICAM1-expressing HUVEC by fluorescence assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Small molecule antagonist of leukocyte function associated antigen-1 (LFA-1): structure-activity relationships leading to the identification of 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinic acid (BMS-688521).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 8.02 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1094128 | — | — | 1 | 8.74 |
| CHEMBL1098727 | — | — | 1 | 8.74 |
| CHEMBL1098726 | — | — | 1 | 8.60 |
| CHEMBL1094115 | — | — | 1 | 8.44 |
| CHEMBL1094127 | — | — | 1 | 8.40 |
| CHEMBL1098437 | — | — | 1 | 8.36 |
| CHEMBL1095138 | — | — | 1 | 8.32 |
| CHEMBL1096088 | — | — | 1 | 8.30 |
| CHEMBL1095148 | — | — | 1 | 8.22 |
| CHEMBL1098760 | — | — | 1 | 8.10 |
| CHEMBL1097733 | — | — | 1 | 7.96 |
| CHEMBL1097384 | — | — | 1 | 7.96 |
| CHEMBL1096039 | — | — | 1 | 7.96 |
| CHEMBL1099103 | — | — | 1 | 7.96 |
| CHEMBL1094753 | — | — | 1 | 7.92 |
| CHEMBL1098761 | — | — | 1 | 7.92 |
| CHEMBL1096053 | — | — | 1 | 7.89 |
| CHEMBL214529 | — | — | 1 | 7.75 |
| CHEMBL1098071 | — | — | 1 | 7.72 |
| CHEMBL1094431 | — | — | 1 | 7.58 |
| CHEMBL1094116 | — | — | 1 | 7.25 |
| CHEMBL1095137 | — | — | 1 | 7.24 |
| CHEMBL1096040 | — | — | 1 | 7.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1094128 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL1098727 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL1098726 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL1094115 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL1094127 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1098437 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL1095138 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL1096088 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1095148 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1098760 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1097733 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1097384 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1096039 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1099103 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1094753 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1098761 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1096053 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL214529 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1098071 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1094431 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL1094116 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL1095137 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL1096040 | — | IC50 | = | 60.0 | nM | 7.22 |