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Assay Detail

CHEMBL1121035

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of NADH oxidase from beef heart submitochondrial particles by spectrophotometry
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Synthesis and evaluation of verticipyrone analogues as mitochondrial complex I inhibitors.
Leiris SJ, Khdour OM, Segerman ZJ, Tsosie KS, Chapuis JC, Hecht SM.
Bioorg Med Chem (2010) 18 : 3481 -3493
PubMed 20456960 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 6.71 8.36

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL429023 ROTENONE 1 8.36
CHEMBL1098149 1 7.45
CHEMBL1097830 1 7.37
CHEMBL1097829 1 7.34
CHEMBL1097833 1 7.32
CHEMBL1097832 1 7.29
CHEMBL1096987 1 7.28
CHEMBL1097831 1 7.26
CHEMBL1097844 1 7.19
CHEMBL1097513 1 7.14
CHEMBL1097514 1 6.66
CHEMBL1097511 1 5.37
CHEMBL1096106 1 4.97
CHEMBL1097845 1 4.87
CHEMBL1097846 1 4.83
CHEMBL1097512 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL429023 ROTENONE IC50 = 4.36 nM 8.36
CHEMBL1098149 IC50 = 35.9 nM 7.45
CHEMBL1097830 IC50 = 43.2 nM 7.37
CHEMBL1097829 IC50 = 45.9 nM 7.34
CHEMBL1097833 IC50 = 47.5 nM 7.32
CHEMBL1097832 IC50 = 50.8 nM 7.29
CHEMBL1096987 IC50 = 52.6 nM 7.28
CHEMBL1097831 IC50 = 55.0 nM 7.26
CHEMBL1097844 IC50 = 64.9 nM 7.19
CHEMBL1097513 IC50 = 72.5 nM 7.14
CHEMBL1097514 IC50 = 218.9 nM 6.66
CHEMBL1097511 IC50 = 4290.0 nM 5.37
CHEMBL1096106 IC50 = 10670.0 nM 4.97
CHEMBL1097845 IC50 = 13590.0 nM 4.87
CHEMBL1097846 IC50 = 14740.0 nM 4.83
CHEMBL1097512 IC50 > 20000.0 nM -