Assay Detail
Functional
CHEMBL1121088
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Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as parasite-specific LDH release after 72 hrs by Malstat assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The bisnaphthalimides as new active lead compounds against Plasmodium falciparum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.11 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1095668 | — | — | 1 | 7.22 |
| CHEMBL1095667 | — | — | 1 | 7.19 |
| CHEMBL1095669 | — | — | 1 | 6.84 |
| CHEMBL1095670 | — | — | 1 | 6.77 |
| CHEMBL1098809 | — | — | 1 | 6.66 |
| CHEMBL269592 | — | — | 1 | 6.40 |
| CHEMBL119701 | — | — | 1 | 6.40 |
| CHEMBL389344 | — | — | 1 | 6.37 |
| CHEMBL1095666 | — | — | 1 | 6.29 |
| CHEMBL1094991 | — | — | 1 | 6.18 |
| CHEMBL1095391 | — | — | 1 | 6.12 |
| CHEMBL8532 | — | — | 1 | 6.10 |
| CHEMBL1095390 | — | — | 1 | 6.05 |
| CHEMBL1134 | DECAMETHONIUM BROMIDE | 4.0 | 1 | 6.04 |
| CHEMBL1094990 | — | — | 1 | 5.46 |
| CHEMBL1094992 | — | — | 1 | 5.17 |
| CHEMBL263972 | — | — | 1 | 5.10 |
| CHEMBL233476 | — | — | 1 | 5.01 |
| CHEMBL1094993 | — | — | 1 | 4.64 |
| CHEMBL1098808 | — | — | 1 | - |
| CHEMBL122587 | — | — | 1 | - |
| CHEMBL1096379 | — | — | 1 | - |
| CHEMBL295786 | — | — | 1 | - |
| CHEMBL332524 | HEXAMETHONIUM BROMIDE | 2.0 | 1 | - |
| CHEMBL1095665 | — | — | 1 | - |
| CHEMBL1095664 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1095668 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1095667 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL1095669 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL1095670 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1098809 | — | IC50 | = | 219.0 | nM | 6.66 |
| CHEMBL269592 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL119701 | — | IC50 | = | 395.0 | nM | 6.40 |
| CHEMBL389344 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL1095666 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL1094991 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL1095391 | — | IC50 | = | 755.0 | nM | 6.12 |
| CHEMBL8532 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1095390 | — | IC50 | = | 892.0 | nM | 6.05 |
| CHEMBL1134 | DECAMETHONIUM BROMIDE | IC50 | = | 911.0 | nM | 6.04 |
| CHEMBL1094990 | — | IC50 | = | 3480.0 | nM | 5.46 |
| CHEMBL1094992 | — | IC50 | = | 6760.0 | nM | 5.17 |
| CHEMBL263972 | — | IC50 | = | 7990.0 | nM | 5.10 |
| CHEMBL233476 | — | IC50 | = | 9810.0 | nM | 5.01 |
| CHEMBL1094993 | — | IC50 | = | 22630.0 | nM | 4.64 |
| CHEMBL1098808 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL122587 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1096379 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL295786 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL332524 | HEXAMETHONIUM BROMIDE | IC50 | > | 100000.0 | nM | - |
| CHEMBL1095665 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1095664 | — | IC50 | > | 100000.0 | nM | - |