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Assay Detail

CHEMBL1166381

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HepG2
Confidence 1 — Organism
Curated By Autocuration

Target

HepG2 (CHEMBL395)
Type CELL-LINE
Organism Homo sapiens

Publication

Cytotoxic N-(fluorenyl-9-methoxycarbonyl) (Fmoc)-dipeptides: structure-activity relationships and synergistic studies.
Yen CT, Wu CC, Lee JC, Chen SL, Morris-Natschke SL, Hsieh PW, Wu YC.
Eur J Med Chem (2010) 45 : 2494 -2502
PubMed 20334960 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 31 8.85 11.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1164093 1 11.00
CHEMBL1163960 1 9.76
CHEMBL1164309 1 9.63
CHEMBL1165664 1 9.60
CHEMBL1163257 1 9.57
CHEMBL554319 1 9.55
CHEMBL1165733 1 9.24
CHEMBL552751 1 9.14
CHEMBL1165138 1 9.01
CHEMBL541177 1 8.85
CHEMBL1163256 1 8.85
CHEMBL1165737 1 8.78
CHEMBL541178 1 8.76
CHEMBL538182 1 8.73
CHEMBL1164409 1 8.72
CHEMBL1163469 1 8.72
CHEMBL1165000 1 8.59
CHEMBL554318 1 8.57
CHEMBL540500 1 7.84
CHEMBL538611 1 7.83
CHEMBL552149 1 7.69
CHEMBL53463 DOXORUBICIN 4.0 1 6.30
CHEMBL1163854 1 -
CHEMBL1163853 1 -
CHEMBL1163252 1 -
CHEMBL1164310 1 -
CHEMBL538183 1 -
CHEMBL1164311 1 -
CHEMBL1163258 1 -
CHEMBL1163259 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1164093 IC50 = 0.01 nM 11.00
CHEMBL1163960 IC50 = 0.174 nM 9.76
CHEMBL1164309 IC50 = 0.232 nM 9.63
CHEMBL1165664 IC50 = 0.25 nM 9.60
CHEMBL1163257 IC50 = 0.269 nM 9.57
CHEMBL554319 IC50 = 0.283 nM 9.55
CHEMBL1165733 IC50 = 0.58 nM 9.24
CHEMBL552751 IC50 = 0.72 nM 9.14
CHEMBL1165138 IC50 = 0.97 nM 9.01
CHEMBL541177 IC50 = 1.41 nM 8.85
CHEMBL1163256 IC50 = 1.42 nM 8.85
CHEMBL1165737 IC50 = 1.65 nM 8.78
CHEMBL541178 IC50 = 1.75 nM 8.76
CHEMBL538182 IC50 = 1.88 nM 8.73
CHEMBL1164409 IC50 = 1.89 nM 8.72
CHEMBL1163469 IC50 = 1.9 nM 8.72
CHEMBL1165000 IC50 = 2.58 nM 8.59
CHEMBL554318 IC50 = 2.69 nM 8.57
CHEMBL540500 IC50 = 14.6 nM 7.84
CHEMBL538611 IC50 = 14.9 nM 7.83
CHEMBL552149 IC50 = 20.3 nM 7.69
CHEMBL53463 DOXORUBICIN IC50 = 500.0 nM 6.30
CHEMBL1163854 IC50 > 55000.0 nM -
CHEMBL1163853 IC50 > 55000.0 nM -
CHEMBL1163252 IC50 > 55000.0 nM -
CHEMBL1164310 IC50 > 55000.0 nM -
CHEMBL538183 IC50 > 55000.0 nM -
CHEMBL1164311 IC50 > 55000.0 nM -
CHEMBL1163258 IC50 > 55000.0 nM -
CHEMBL1163259 IC50 > 55000.0 nM -
CHEMBL1164411 IC50 > 55000.0 nM -