Assay Detail
Binding
CHEMBL1166428
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Inhibition of Cryptosporidium parvum recombinant H6-NBD1 of ABC3 transporter ATPase activity expressed in Escherichia coli BL21(DE3) after 10 mins
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cryptosporidium parvum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and modulation properties of imidazo[4,5-b]pyridin-7-one and indazole-4,7-dione derivatives towards the Cryptosporidium parvum CpABC3 transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 4.44 | 4.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1163419 | TNP-ATP | — | 1 | 4.44 |
| CHEMBL1164620 | — | — | 1 | - |
| CHEMBL1165780 | — | — | 1 | - |
| CHEMBL1164799 | — | — | 1 | - |
| CHEMBL1165539 | — | — | 1 | - |
| CHEMBL1164896 | — | — | 1 | - |
| CHEMBL1165488 | — | — | 1 | - |
| CHEMBL1165594 | — | — | 1 | - |
| CHEMBL103 | PROGESTERONE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1163419 | TNP-ATP | Ki | = | 36600.0 | nM | 4.44 |
| CHEMBL1164620 | — | Ki | - | — | - | |
| CHEMBL1165780 | — | Ki | - | — | - | |
| CHEMBL1164799 | — | Ki | = | 232000.0 | nM | - |
| CHEMBL1165539 | — | Ki | = | 538900.0 | nM | - |
| CHEMBL1164896 | — | Ki | - | — | - | |
| CHEMBL1165488 | — | Ki | - | — | - | |
| CHEMBL1165594 | — | Ki | = | 116100.0 | nM | - |
| CHEMBL103 | PROGESTERONE | Ki | - | — | - |