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Assay Detail

CHEMBL1166734

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of HDAC in human HeLa cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type HeLa
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Histone deacetylase (CHEMBL2093865)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Inside HDAC with HDAC inhibitors.
Bertrand P.
Eur J Med Chem (2010) 45 : 2095 -2116
PubMed 20223566 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 6.59 7.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1164046 1 7.72
CHEMBL1165336 1 7.40
CHEMBL112234 1 7.14
CHEMBL112105 1 7.10
CHEMBL325676 1 6.68
CHEMBL1164599 1 6.52
CHEMBL178858 1 6.05
CHEMBL178456 1 6.05
CHEMBL1163375 1 5.70
CHEMBL1164670 1 5.57
CHEMBL1164592 1 -
CHEMBL1165337 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1164046 IC50 = 19.0 nM 7.72
CHEMBL1165336 IC50 = 40.0 nM 7.40
CHEMBL112234 IC50 = 72.0 nM 7.14
CHEMBL112105 IC50 = 79.0 nM 7.10
CHEMBL325676 IC50 = 210.0 nM 6.68
CHEMBL1164599 IC50 = 300.0 nM 6.52
CHEMBL178858 IC50 = 900.0 nM 6.05
CHEMBL178456 IC50 = 900.0 nM 6.05
CHEMBL1163375 IC50 = 2000.0 nM 5.70
CHEMBL1164670 IC50 = 2700.0 nM 5.57
CHEMBL1164592 IC50 < 1.0 nM -
CHEMBL1165337 IC50 > 10000.0 nM -