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Assay Detail

CHEMBL1166941

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of IL5-mediated proliferation of mouse Y16 cells by WST1 assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Mus musculus
Cell Type Y16
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Interleukin-5 (CHEMBL1163111)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

The scope of thallium nitrate oxidative cyclization of chalcones; synthesis and evaluation of isoflavone and aurone analogs for their inhibitory activity against interleukin-5.
Thanigaimalai P, Yang HM, Sharma VK, Kim Y, Jung SH.
Bioorg Med Chem (2010) 18 : 4441 -4445
PubMed 20472438 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 5.13 5.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL486626 SOPHORICOSIDE 1 5.85
CHEMBL1164199 1 5.24
CHEMBL1163759 1 5.21
CHEMBL1163986 1 4.76
CHEMBL1370 BUDESONIDE 4.0 1 4.58
CHEMBL1164200 1 -
CHEMBL1165285 1 -
CHEMBL1165286 1 -
CHEMBL1165801 1 -
CHEMBL1163987 1 -
CHEMBL1163830 1 -
CHEMBL1165498 1 -
CHEMBL1164395 1 -
CHEMBL1163212 1 -
CHEMBL1165763 1 -
CHEMBL1163908 1 -
CHEMBL1164394 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL486626 SOPHORICOSIDE IC50 = 1400.0 nM 5.85
CHEMBL1164199 IC50 = 5800.0 nM 5.24
CHEMBL1163759 IC50 = 6100.0 nM 5.21
CHEMBL1163986 IC50 = 17400.0 nM 4.76
CHEMBL1370 BUDESONIDE IC50 = 26200.0 nM 4.58
CHEMBL1164200 IC50 > 30000.0 nM -
CHEMBL1165285 IC50 > 30000.0 nM -
CHEMBL1165286 IC50 > 30000.0 nM -
CHEMBL1165801 IC50 > 30000.0 nM -
CHEMBL1163987 IC50 > 30000.0 nM -
CHEMBL1163830 IC50 > 30000.0 nM -
CHEMBL1165498 IC50 > 30000.0 nM -
CHEMBL1164395 IC50 > 30000.0 nM -
CHEMBL1163212 IC50 > 30000.0 nM -
CHEMBL1165763 IC50 > 30000.0 nM -
CHEMBL1163908 IC50 > 30000.0 nM -
CHEMBL1164394 IC50 > 30000.0 nM -