Assay Detail
Binding
CHEMBL1167023
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human N-terminal His6-tagged 5-lipoxygenase arachidonic acid by UV-vis spectrometry
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.82 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | — | 1 | 6.96 |
| CHEMBL425166 | JASPAQUINOL | — | 1 | 6.35 |
| CHEMBL1164975 | — | — | 1 | 6.30 |
| CHEMBL157844 | PUUPEHENONE | — | 1 | 6.17 |
| CHEMBL1163875 | PUUPEHEDIONE | — | 1 | 5.34 |
| CHEMBL180947 | JASPIC ACID | — | 1 | 4.85 |
| CHEMBL1164369 | ISOJASPIC ACID | — | 1 | 4.75 |
| CHEMBL1165243 | — | — | 1 | - |
| CHEMBL1165577 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL425166 | JASPAQUINOL | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL1164975 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL157844 | PUUPEHENONE | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL1163875 | PUUPEHEDIONE | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL180947 | JASPIC ACID | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL1164369 | ISOJASPIC ACID | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL1165243 | — | IC50 | > | 150000.0 | nM | - |
| CHEMBL1165577 | — | IC50 | > | 50000.0 | nM | - |