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Assay Detail

CHEMBL1167025

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Selectivity ratio of IC50 for human reticulocyte 15-lipoxygenase to IC50 for human 5-lipoxygenase
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes.
Robinson SJ, Hoobler EK, Riener M, Loveridge ST, Tenney K, Valeriote FA, Holman TR, Crews P.
J Nat Prod (2009) 72 : 1857 -1863
PubMed 19848434 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 8 5.47 6.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL180947 JASPIC ACID 1 6.52
CHEMBL1164369 ISOJASPIC ACID 1 6.05
CHEMBL1163875 PUUPEHEDIONE 1 5.82
CHEMBL1165577 1 5.52
CHEMBL157844 PUUPEHENONE 1 5.05
CHEMBL52 NORDIHYDROGUAIARETIC ACID 1 4.96
CHEMBL425166 JASPAQUINOL 1 4.38
CHEMBL1164975 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL180947 JASPIC ACID IC50 = 300.0 nM 6.52
CHEMBL1164369 ISOJASPIC ACID IC50 = 900.0 nM 6.05
CHEMBL1163875 PUUPEHEDIONE IC50 = 1500.0 nM 5.82
CHEMBL1165577 IC50 = 3000.0 nM 5.52
CHEMBL157844 PUUPEHENONE IC50 = 9000.0 nM 5.05
CHEMBL52 NORDIHYDROGUAIARETIC ACID IC50 = 11000.0 nM 4.96
CHEMBL425166 JASPAQUINOL IC50 = 42000.0 nM 4.38
CHEMBL1164975 IC50 > 200000.0 nM -