Assay Detail
Functional
CHEMBL1167883
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Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, cytotoxicity, anti-oxidative and anti-inflammatory activity of chalcones and influence of A-ring modifications on the pharmacological effect.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.81 | 5.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1164817 | — | — | 1 | 5.14 |
| CHEMBL253896 | XANTHOHUMOL | 2.0 | 1 | 5.03 |
| CHEMBL1165326 | — | — | 1 | 4.98 |
| CHEMBL1165313 | — | — | 1 | 4.81 |
| CHEMBL1165452 | — | — | 1 | 4.81 |
| CHEMBL1164296 | — | — | 1 | 4.81 |
| CHEMBL1164816 | — | — | 1 | 4.80 |
| CHEMBL1165248 | — | — | 1 | 4.48 |
| CHEMBL1165249 | — | — | 1 | 4.43 |
| CHEMBL589608 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1164817 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL253896 | XANTHOHUMOL | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL1165326 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL1165313 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL1165452 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL1164296 | — | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL1164816 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL1165248 | — | IC50 | = | 32800.0 | nM | 4.48 |
| CHEMBL1165249 | — | IC50 | = | 36900.0 | nM | 4.43 |
| CHEMBL589608 | — | IC50 | > | 50000.0 | nM | - |