Assay Detail
Binding
CHEMBL1167927
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of human glucokinase expressed in Escherichia coli BL21(DE3) coexpressing G6PDH by spectrometry
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Design, synthesis, and pharmacological evaluation of N-(4-mono and 4,5-disubstituted thiazol-2-yl)-2-aryl-3-(tetrahydro-2H-pyran-4-yl)propanamides as glucokinase activators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 29 | 6.42 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1165653 | — | — | 1 | 7.58 |
| CHEMBL205627 | — | — | 1 | 7.52 |
| CHEMBL499520 | — | — | 1 | 7.21 |
| CHEMBL1165284 | — | — | 1 | 7.21 |
| CHEMBL1164790 | — | — | 1 | 7.10 |
| CHEMBL1164184 | — | — | 1 | 7.05 |
| CHEMBL1165817 | — | — | 1 | 6.92 |
| CHEMBL1164578 | — | — | 1 | 6.80 |
| CHEMBL1165587 | — | — | 1 | 6.80 |
| CHEMBL1165042 | — | — | 1 | 6.51 |
| CHEMBL1164519 | — | — | 1 | 6.50 |
| CHEMBL1164577 | — | — | 1 | 6.48 |
| CHEMBL1164315 | — | — | 1 | 6.45 |
| CHEMBL517534 | — | — | 1 | 6.24 |
| CHEMBL1164323 | — | — | 1 | 6.14 |
| CHEMBL1164268 | — | — | 1 | 6.00 |
| CHEMBL1165056 | — | — | 1 | 5.98 |
| CHEMBL1164508 | — | — | 1 | 5.93 |
| CHEMBL1164970 | — | — | 1 | 5.87 |
| CHEMBL519934 | — | — | 1 | 5.77 |
| CHEMBL1165213 | — | — | 1 | 5.54 |
| CHEMBL1164579 | — | — | 1 | 5.54 |
| CHEMBL1165692 | — | — | 1 | 5.53 |
| CHEMBL1165294 | — | — | 1 | 5.33 |
| CHEMBL1164726 | — | — | 1 | - |
| CHEMBL1165479 | — | — | 1 | - |
| CHEMBL1164587 | — | — | 1 | - |
| CHEMBL1164586 | — | — | 1 | - |
| CHEMBL1164848 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1165653 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL205627 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL499520 | — | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL1165284 | — | EC50 | = | 61.0 | nM | 7.21 |
| CHEMBL1164790 | — | EC50 | = | 79.0 | nM | 7.10 |
| CHEMBL1164184 | — | EC50 | = | 89.0 | nM | 7.05 |
| CHEMBL1165817 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1164578 | — | EC50 | = | 157.0 | nM | 6.80 |
| CHEMBL1165587 | — | EC50 | = | 158.0 | nM | 6.80 |
| CHEMBL1165042 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL1164519 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL1164577 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL1164315 | — | EC50 | = | 355.0 | nM | 6.45 |
| CHEMBL517534 | — | EC50 | = | 570.0 | nM | 6.24 |
| CHEMBL1164323 | — | EC50 | = | 724.0 | nM | 6.14 |
| CHEMBL1164268 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1165056 | — | EC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL1164508 | — | EC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL1164970 | — | EC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL519934 | — | EC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL1165213 | — | EC50 | = | 2860.0 | nM | 5.54 |
| CHEMBL1164579 | — | EC50 | = | 2860.0 | nM | 5.54 |
| CHEMBL1165692 | — | EC50 | = | 2930.0 | nM | 5.53 |
| CHEMBL1165294 | — | EC50 | = | 4680.0 | nM | 5.33 |
| CHEMBL1164726 | — | EC50 | - | — | - | |
| CHEMBL1165479 | — | EC50 | - | — | - | |
| CHEMBL1164587 | — | EC50 | - | — | - | |
| CHEMBL1164586 | — | EC50 | - | — | - | |
| CHEMBL1164848 | — | EC50 | - | — | - |