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Assay Detail

CHEMBL1168871

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ADMET
Cytotoxicity against human NHDF cells by MTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type NHDF
Confidence 1 — Organism
Curated By Autocuration

Target

NHDF (CHEMBL614200)
Type CELL-LINE
Organism Homo sapiens

Publication

Simple di- and trivanillates exhibit cytostatic properties toward cancer cells resistant to pro-apoptotic stimuli.
Lamoral-Theys D, Pottier L, Kerff F, Dufrasne F, Proutière F, Wauthoz N, Neven P, Ingrassia L, Antwerpen PV, Lefranc F, Gelbcke M, Pirotte B, Kraus JL, Nève J, Kornienko A, Kiss R, Dubois J.
Bioorg Med Chem (2010) 18 : 3823 -3833
PubMed 20466556 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 4.22 4.54

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1163780 1 4.54
CHEMBL1163275 1 4.52
CHEMBL1164313 1 4.50
CHEMBL1165205 1 4.43
CHEMBL1163276 1 4.16
CHEMBL1164100 1 4.14
CHEMBL1164468 1 4.10
CHEMBL1164564 1 4.09
CHEMBL1165527 1 4.08
CHEMBL1164872 1 4.05
CHEMBL1163821 1 4.04
CHEMBL1165533 1 4.02
CHEMBL1164563 1 -
CHEMBL1163826 1 -
CHEMBL1163758 1 -
CHEMBL1163757 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1163780 IC50 = 29000.0 nM 4.54
CHEMBL1163275 IC50 = 30000.0 nM 4.52
CHEMBL1164313 IC50 = 32000.0 nM 4.50
CHEMBL1165205 IC50 = 37000.0 nM 4.43
CHEMBL1163276 IC50 = 69000.0 nM 4.16
CHEMBL1164100 IC50 = 72000.0 nM 4.14
CHEMBL1164468 IC50 = 79000.0 nM 4.10
CHEMBL1164564 IC50 = 81000.0 nM 4.09
CHEMBL1165527 IC50 = 84000.0 nM 4.08
CHEMBL1164872 IC50 = 89000.0 nM 4.05
CHEMBL1163821 IC50 = 92000.0 nM 4.04
CHEMBL1165533 IC50 = 95000.0 nM 4.02
CHEMBL1164563 IC50 > 100000.0 nM -
CHEMBL1163826 IC50 > 100000.0 nM -
CHEMBL1163758 IC50 > 100000.0 nM -
CHEMBL1163757 IC50 > 100000.0 nM -