Assay Detail
Functional
CHEMBL1173858
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Agonist activity at human TPO receptor expressed in rat BaF3 cells
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BaF3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationships and hepatic safety risks of thiazole agonists of the thrombopoietin receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 6.70 | 7.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL523975 | — | — | 1 | 7.48 |
| CHEMBL1170197 | — | — | 1 | 7.24 |
| CHEMBL1172354 | — | — | 1 | 7.18 |
| CHEMBL1172355 | — | — | 1 | 7.07 |
| CHEMBL1170611 | — | — | 1 | 7.05 |
| CHEMBL1171610 | — | — | 1 | 7.00 |
| CHEMBL1171784 | — | — | 1 | 6.89 |
| CHEMBL1171783 | — | — | 1 | 6.80 |
| CHEMBL1170004 | — | — | 1 | 6.66 |
| CHEMBL1172356 | — | — | 1 | 6.32 |
| CHEMBL1169647 | — | — | 1 | 6.24 |
| CHEMBL1170600 | — | — | 1 | 6.21 |
| CHEMBL1170598 | — | — | 1 | 6.17 |
| CHEMBL1171609 | — | — | 1 | 6.15 |
| CHEMBL1169816 | — | — | 1 | 6.02 |
| CHEMBL1169815 | — | — | 1 | - |
| CHEMBL1170599 | — | — | 1 | - |
| CHEMBL1170003 | — | — | 1 | - |
| CHEMBL1169646 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL523975 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL1170197 | — | EC50 | = | 58.0 | nM | 7.24 |
| CHEMBL1172354 | — | EC50 | = | 66.0 | nM | 7.18 |
| CHEMBL1172355 | — | EC50 | = | 86.0 | nM | 7.07 |
| CHEMBL1170611 | — | EC50 | = | 89.0 | nM | 7.05 |
| CHEMBL1171610 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1171784 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1171783 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1170004 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1172356 | — | EC50 | = | 480.0 | nM | 6.32 |
| CHEMBL1169647 | — | EC50 | = | 574.0 | nM | 6.24 |
| CHEMBL1170600 | — | EC50 | = | 620.0 | nM | 6.21 |
| CHEMBL1170598 | — | EC50 | = | 670.0 | nM | 6.17 |
| CHEMBL1171609 | — | EC50 | = | 702.0 | nM | 6.15 |
| CHEMBL1169816 | — | EC50 | = | 950.0 | nM | 6.02 |
| CHEMBL1169815 | — | EC50 | > | 811.0 | nM | - |
| CHEMBL1170599 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL1170003 | — | EC50 | > | 970.0 | nM | - |
| CHEMBL1169646 | — | EC50 | > | 898.0 | nM | - |