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Assay Detail

CHEMBL1174227

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Functional
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A549
Confidence 1 — Organism
Curated By Autocuration

Target

A549 (CHEMBL392)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and preliminary biological evaluation of novel taspine derivatives as anticancer agents.
Zhang J, Zhang Y, Shan Y, Li N, Ma W, He L.
Eur J Med Chem (2010) 45 : 2798 -2805
PubMed 20304537 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 4.57 5.38

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL470867 TASPINE 1 5.38
CHEMBL1170014 1 4.19
CHEMBL1170015 1 4.13
CHEMBL593123 1 -
CHEMBL595922 1 -
CHEMBL593143 1 -
CHEMBL1172440 1 -
CHEMBL1172158 1 -
CHEMBL1172627 1 -
CHEMBL1172628 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL470867 TASPINE IC50 = 4180.0 nM 5.38
CHEMBL1170014 IC50 = 64650.0 nM 4.19
CHEMBL1170015 IC50 = 73510.0 nM 4.13
CHEMBL593123 IC50 = 453000.0 nM -
CHEMBL595922 IC50 = 158000.0 nM -
CHEMBL593143 IC50 = 180000.0 nM -
CHEMBL1172440 IC50 = 111000.0 nM -
CHEMBL1172158 IC50 = 259490.0 nM -
CHEMBL1172627 IC50 = 194390.0 nM -
CHEMBL1172628 IC50 = 240510.0 nM -