Assay Detail
Binding
CHEMBL1174296
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Inhibition of human neutrophil elastase after 30 mins by ELISA
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of benzoxazinone derivatives on activity of human neutrophil elastase and on hemorrhagic shock-induced lung injury in rats.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.75 | 7.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1172443 | — | — | 1 | 7.61 |
| CHEMBL1172265 | — | — | 1 | 7.51 |
| CHEMBL1172307 | — | — | 1 | 7.40 |
| CHEMBL1172305 | — | — | 1 | 7.28 |
| CHEMBL1172306 | — | — | 1 | 7.24 |
| CHEMBL1172107 | — | — | 1 | 6.21 |
| CHEMBL190503 | PHENYLMETHYLSULFONYLFLUORIDE | — | 1 | 4.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1172443 | — | IC50 | = | 24.8 | nM | 7.61 |
| CHEMBL1172265 | — | IC50 | = | 30.7 | nM | 7.51 |
| CHEMBL1172307 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1172305 | — | IC50 | = | 52.7 | nM | 7.28 |
| CHEMBL1172306 | — | IC50 | = | 57.1 | nM | 7.24 |
| CHEMBL1172107 | — | IC50 | = | 612.4 | nM | 6.21 |
| CHEMBL190503 | PHENYLMETHYLSULFONYLFLUORIDE | IC50 | = | 95219.3 | nM | 4.02 |