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Assay Detail

CHEMBL1174785

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Functional
Antiprotozoal activity against Entamoeba histolytica HM-1:IMSS after 48 hrs
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Entamoeba histolytica
Confidence 1 — Organism
Curated By Autocuration

Target

Entamoeba histolytica (CHEMBL612853)
Type ORGANISM
Organism Entamoeba histolytica

Publication

Synthesis and biological activity of 2-(trifluoromethyl)-1H-benzimidazole derivatives against some protozoa and Trichinella spiralis.
Hernández-Luis F, Hernández-Campos A, Castillo R, Navarrete-Vázquez G, Soria-Arteche O, Hernández-Hernández M, Yépez-Mulia L.
Eur J Med Chem (2010) 45 : 3135 -3141
PubMed 20430484 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 7.29 8.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1170756 1 8.05
CHEMBL56234 1 7.96
CHEMBL1170159 1 7.77
CHEMBL1172446 1 7.75
CHEMBL1170157 1 7.72
CHEMBL1170757 1 7.72
CHEMBL1169965 1 7.70
CHEMBL1170158 1 7.42
CHEMBL56473 1 7.34
CHEMBL137 METRONIDAZOLE 4.0 1 6.46
CHEMBL1483 ALBENDAZOLE 4.0 1 4.25
CHEMBL55 PENTAMIDINE 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1170756 IC50 = 9.0 nM 8.05
CHEMBL56234 IC50 = 11.0 nM 7.96
CHEMBL1170159 IC50 = 17.0 nM 7.77
CHEMBL1172446 IC50 = 18.0 nM 7.75
CHEMBL1170157 IC50 = 19.0 nM 7.72
CHEMBL1170757 IC50 = 19.0 nM 7.72
CHEMBL1169965 IC50 = 20.0 nM 7.70
CHEMBL1170158 IC50 = 38.0 nM 7.42
CHEMBL56473 IC50 = 46.0 nM 7.34
CHEMBL137 METRONIDAZOLE IC50 = 350.0 nM 6.46
CHEMBL1483 ALBENDAZOLE IC50 = 56600.0 nM 4.25
CHEMBL55 PENTAMIDINE IC50 - -