Assay Detail
Binding
CHEMBL1175135
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Binding affinity to OX2R
11
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of 3,9-diazabicyclo[4.2.1]nonanes as potent dual orexin receptor antagonists with sleep-promoting activity in the rat.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 8.23 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1171594 | — | — | 2 | 9.40 |
| CHEMBL469146 | — | — | 1 | 9.22 |
| CHEMBL1172520 | — | — | 1 | 9.22 |
| CHEMBL1170803 | — | — | 1 | 9.10 |
| CHEMBL1170178 | — | — | 1 | 8.66 |
| CHEMBL1172519 | — | — | 1 | 8.54 |
| CHEMBL1170179 | — | — | 1 | 7.85 |
| CHEMBL1171595 | — | — | 1 | 7.21 |
| CHEMBL1171766 | — | — | 1 | 6.98 |
| CHEMBL1171767 | — | — | 1 | 6.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1171594 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL469146 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL1172520 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL1170803 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL1170178 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL1172519 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL1171594 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL1170179 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL1171595 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL1171766 | — | Ki | = | 105.0 | nM | 6.98 |
| CHEMBL1171767 | — | Ki | = | 590.0 | nM | 6.23 |