Assay Detail
Binding
CHEMBL1175752
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Thermus aquaticus taq polymerase
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Thermus aquaticus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and molecular docking studies of novel 2-chloro-pyridine derivatives containing flavone moieties as potential antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.04 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1169924 | — | — | 1 | 5.70 |
| CHEMBL1169925 | — | — | 1 | 5.30 |
| CHEMBL1170702 | — | — | 1 | 5.19 |
| CHEMBL1172458 | — | — | 1 | 5.17 |
| CHEMBL1170488 | — | — | 1 | 5.12 |
| CHEMBL1171697 | — | — | 1 | 4.56 |
| CHEMBL1171529 | — | — | 1 | 4.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1169924 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1169925 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1170702 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL1172458 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL1170488 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL1171697 | — | IC50 | = | 27500.0 | nM | 4.56 |
| CHEMBL1171529 | — | IC50 | = | 53200.0 | nM | 4.27 |