Assay Detail
Functional
CHEMBL1175827
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of [14C]-oleic acid oxidation in human differentiated skeletal muscle cells assessed as accumulation of oxidized [14C]-oleic acid after 4 hrs by by liquid scintillation counting
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and dual PPARalpha/delta agonist effects of 1,4-disubstituted 1,2,3-triazole analogues of GW 501516.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 8.79 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38943 | GW501516 | 2.0 | 1 | 10.15 |
| CHEMBL1170332 | — | — | 1 | 9.07 |
| CHEMBL1170156 | — | — | 1 | 8.85 |
| CHEMBL1170331 | — | — | 1 | 8.74 |
| CHEMBL1172486 | — | — | 1 | 8.00 |
| CHEMBL1170155 | — | — | 1 | 7.92 |
| CHEMBL1170154 | — | — | 1 | - |
| CHEMBL1172264 | — | — | 1 | - |
| CHEMBL1172475 | — | — | 1 | - |
| CHEMBL1172445 | — | — | 1 | - |
| CHEMBL1170540 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38943 | GW501516 | EC50 | = | 0.07 | nM | 10.15 |
| CHEMBL1170332 | — | EC50 | = | 0.85 | nM | 9.07 |
| CHEMBL1170156 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL1170331 | — | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL1172486 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1170155 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1170154 | — | EC50 | - | — | - | |
| CHEMBL1172264 | — | EC50 | - | — | - | |
| CHEMBL1172475 | — | EC50 | - | — | - | |
| CHEMBL1172445 | — | EC50 | - | — | - | |
| CHEMBL1170540 | — | EC50 | - | — | - |