Assay Detail
Binding
CHEMBL1176404
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Selectivity ratio of Ki for human cloned 5HT2C receptor to Ki for human cloned 5HT2A receptor
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Serotonin 2 receptors; 5-HT2a & 5-HT2c (CHEMBL2096662) ↗| Type | SELECTIVITY GROUP |
| Organism | Homo sapiens |
Publication
Synthesis and structure-affinity relationships of novel small molecule natural product derivatives capable of discriminating between serotonin 5-HT1A, 5-HT2A, 5-HT2C receptor subtypes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 34 | 7.79 | 10.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1172812 | — | — | 1 | 10.48 |
| CHEMBL404232 | APLYSINOPSIN | — | 1 | 10.39 |
| CHEMBL1173408 | — | — | 1 | 10.10 |
| CHEMBL1173820 | — | — | 1 | 9.96 |
| CHEMBL41347 | — | — | 1 | 8.22 |
| CHEMBL93850 | — | — | 1 | 7.89 |
| CHEMBL43916 | — | — | 1 | 7.80 |
| CHEMBL42463 | — | — | 1 | 7.80 |
| CHEMBL38911 | — | — | 1 | 7.80 |
| CHEMBL296090 | — | — | 1 | 7.70 |
| CHEMBL289063 | — | — | 1 | 7.60 |
| CHEMBL42024 | — | — | 1 | 7.60 |
| CHEMBL96883 | — | — | 1 | 7.60 |
| CHEMBL328844 | — | — | 1 | 7.60 |
| CHEMBL297043 | — | — | 1 | 7.50 |
| CHEMBL43929 | — | — | 1 | 7.50 |
| CHEMBL290395 | — | — | 1 | 7.50 |
| CHEMBL276673 | — | — | 1 | 7.40 |
| CHEMBL44095 | — | — | 1 | 7.40 |
| CHEMBL92656 | — | — | 1 | 7.20 |
| CHEMBL299530 | — | — | 1 | 7.10 |
| CHEMBL299726 | — | — | 1 | 7.10 |
| CHEMBL42276 | — | — | 1 | 7.00 |
| CHEMBL40726 | — | — | 1 | 7.00 |
| CHEMBL301784 | — | — | 1 | 6.90 |
| CHEMBL433060 | — | — | 1 | 6.30 |
| CHEMBL54769 | — | — | 1 | 5.90 |
| CHEMBL1173333 | — | — | 1 | - |
| CHEMBL463249 | — | — | 1 | - |
| CHEMBL1173334 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1172812 | — | Ki | = | 0.033 | nM | 10.48 |
| CHEMBL404232 | APLYSINOPSIN | Ki | = | 0.041 | nM | 10.39 |
| CHEMBL1173408 | — | Ki | = | 0.079 | nM | 10.10 |
| CHEMBL1173820 | — | Ki | = | 0.11 | nM | 9.96 |
| CHEMBL41347 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL93850 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL43916 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL42463 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL38911 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL296090 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL289063 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL42024 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL96883 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL328844 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL290395 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL297043 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL43929 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL276673 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL44095 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL92656 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL299530 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL299726 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL42276 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL40726 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL301784 | — | Ki | = | 126.0 | nM | 6.90 |
| CHEMBL433060 | — | Ki | = | 502.0 | nM | 6.30 |
| CHEMBL54769 | — | Ki | = | 1260.0 | nM | 5.90 |
| CHEMBL1173333 | — | Ki | > | 602.0 | nM | - |
| CHEMBL463249 | — | Ki | > | 45.0 | nM | - |
| CHEMBL1173334 | — | Ki | > | 2170.0 | nM | - |
| CHEMBL56232 | — | Ki | > | 100.0 | nM | - |
| CHEMBL55958 | — | Ki | > | 251.0 | nM | - |
| CHEMBL59097 | — | Ki | > | 1585.0 | nM | - |
| CHEMBL42327 | — | Ki | > | 8.0 | nM | - |