Assay Detail
Binding
CHEMBL1176449
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Gli1 expressed in mouse C3H10T1/2 cells assessed as inhibition of transcriptional activity after 24 hrs by luciferase reporter gene assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | C3H 10T1/2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Amide conjugates of ketoprofen and indole as inhibitors of Gli1-mediated transcription in the Hedgehog pathway.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.69 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1172835 | — | — | 1 | 5.80 |
| CHEMBL1173148 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1172835 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1173148 | — | IC50 | = | 2600.0 | nM | 5.58 |