Assay Detail

CHEMBL1176742

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Binding

Displacement of [3H]-citalopram from SERT in mouse cortex after 2 hrs by liquid scintillation counting

ChEMBL ↗

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Target

Sodium-dependent serotonin transporter (CHEMBL4642) ↗

Open DB target context

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Primary target Sodium-dependent serotonin transporter

CHEMBL4642

Anchored from Assay target.

Protein identity Sodium-dependent serotonin transporter

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Mus musculus
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Sodium-dependent serotonin transporter (CHEMBL4642) ↗

Type	SINGLE PROTEIN
Organism	Mus musculus

Publication

6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane: a new potent and selective triple reuptake inhibitor.

Micheli F, Cavanni P, Andreotti D, Arban R, Benedetti R, Bertani B, Bettati M, Bettelini L, Bonanomi G, Braggio S, Carletti R, Checchia A, Corsi M, Fazzolari E, Fontana S, Marchioro C, Merlo-Pich E, Negri M, Oliosi B, Ratti E, Read KD, Roscic M, Sartori I, Spada S, Tedesco G, Tarsi L, Terreni S, Visentini F, Zocchi A, Zonzini L, Di Fabio R.
J Med Chem (2010) 53 : 4989 -5001
PubMed 20527970 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	8.80	8.80

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1173532	GSK1360707	1.0	1	8.80

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1173532	GSK1360707	Ki	=	1.585	nM	8.80