Assay Detail
Functional
CHEMBL1176807
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Antiproliferative activity against mouse L1210 cells after 2 days by coulter counting
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Substituted 2-(3',4',5'-trimethoxybenzoyl)-benzo[b]thiophene derivatives as potent tubulin polymerization inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.99 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.55 |
| CHEMBL1171846 | — | — | 1 | 7.72 |
| CHEMBL1173006 | — | — | 1 | 7.60 |
| CHEMBL1172941 | — | — | 1 | 7.52 |
| CHEMBL227027 | — | — | 1 | 7.48 |
| CHEMBL227987 | — | — | 1 | 7.41 |
| CHEMBL1171666 | — | — | 1 | 7.08 |
| CHEMBL1171493 | — | — | 1 | 7.06 |
| CHEMBL1173437 | — | — | 1 | 7.00 |
| CHEMBL1173439 | — | — | 1 | 6.89 |
| CHEMBL1171667 | — | — | 1 | 6.85 |
| CHEMBL1171979 | — | — | 1 | 6.31 |
| CHEMBL1171664 | — | — | 1 | 6.24 |
| CHEMBL1170869 | — | — | 1 | 6.22 |
| CHEMBL1170872 | — | — | 1 | 5.96 |
| CHEMBL1171665 | — | — | 1 | 5.92 |
| CHEMBL228167 | — | — | 1 | - |
| CHEMBL228054 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL1171846 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1173006 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1172941 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL227027 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL227987 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL1171666 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL1171493 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL1173437 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1173439 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1171667 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1171979 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL1171664 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL1170869 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1170872 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1171665 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL228167 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL228054 | — | IC50 | > | 10000.0 | nM | - |