Assay Detail
Functional
CHEMBL1176967
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Growth inhibition of mouse SC3 cells after 3 days by WST-8 assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | SC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of androgen receptor full antagonists bearing a p-carborane cage: promising ligands for anti-androgen withdrawal syndrome.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.54 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL63560 | (R)-BICALUTAMIDE | — | 1 | 6.85 |
| CHEMBL491 | HYDROXYFLUTAMIDE | 2.0 | 1 | 6.62 |
| CHEMBL806 | FLUTAMIDE | 4.0 | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL63560 | (R)-BICALUTAMIDE | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL491 | HYDROXYFLUTAMIDE | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL806 | FLUTAMIDE | IC50 | = | 720.0 | nM | 6.14 |