Assay Detail
Functional
CHEMBL1176994
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HT-29 cells under aerobic condition after 5 days by SRB assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Hypoxic selectivity and solubility--investigating the properties of A-ring substituted nitro seco-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-ones (nitroCBIs) as hypoxia-activated prodrugs for antitumor therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.88 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1171845 | — | — | 1 | 7.62 |
| CHEMBL585201 | — | — | 1 | 7.46 |
| CHEMBL1172173 | — | — | 1 | 6.14 |
| CHEMBL1171982 | — | — | 1 | 5.96 |
| CHEMBL1172175 | — | — | 1 | 5.89 |
| CHEMBL1172174 | — | — | 1 | 5.82 |
| CHEMBL1172218 | — | — | 1 | 5.75 |
| CHEMBL1171844 | — | — | 1 | 5.57 |
| CHEMBL570414 | — | — | 1 | 5.34 |
| CHEMBL1172008 | — | — | 1 | 4.62 |
| CHEMBL1172009 | — | — | 1 | 4.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1171845 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL585201 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL1172173 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL1171982 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1172175 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1172174 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1172218 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1171844 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL570414 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL1172008 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL1172009 | — | IC50 | = | 31000.0 | nM | 4.51 |