Assay Detail
Binding
CHEMBL1177153
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Inhibition of interleukin-5 in mouse Y16 cells
19
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | Y16 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of novel hydroxyalkylaminomethylchromones for their IL-5 inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 4.77 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL486626 | SOPHORICOSIDE | — | 2 | 5.85 |
| CHEMBL1173222 | — | — | 1 | 4.76 |
| CHEMBL1173822 | — | — | 1 | 4.73 |
| CHEMBL1172768 | — | — | 1 | 4.59 |
| CHEMBL1370 | BUDESONIDE | 4.0 | 1 | 4.58 |
| CHEMBL1172608 | — | — | 1 | 4.58 |
| CHEMBL1172607 | — | — | 1 | 4.58 |
| CHEMBL1173246 | — | — | 1 | 4.56 |
| CHEMBL1172888 | — | — | 1 | 4.54 |
| CHEMBL1172767 | — | — | 1 | - |
| CHEMBL1173223 | — | — | 1 | - |
| CHEMBL1173224 | — | — | 1 | - |
| CHEMBL1172423 | — | — | 1 | - |
| CHEMBL1173176 | — | — | 1 | - |
| CHEMBL1173175 | — | — | 1 | - |
| CHEMBL1171983 | — | — | 1 | - |
| CHEMBL1172889 | — | — | 1 | - |
| CHEMBL1173245 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL486626 | SOPHORICOSIDE | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL486626 | SOPHORICOSIDE | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL1173222 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL1173822 | — | IC50 | = | 18500.0 | nM | 4.73 |
| CHEMBL1172768 | — | IC50 | = | 25700.0 | nM | 4.59 |
| CHEMBL1370 | BUDESONIDE | IC50 | = | 26200.0 | nM | 4.58 |
| CHEMBL1172608 | — | IC50 | = | 26200.0 | nM | 4.58 |
| CHEMBL1172607 | — | IC50 | = | 26400.0 | nM | 4.58 |
| CHEMBL1173246 | — | IC50 | = | 27300.0 | nM | 4.56 |
| CHEMBL1172888 | — | IC50 | = | 28500.0 | nM | 4.54 |
| CHEMBL1173245 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1171983 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1173175 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1173176 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1172423 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1172889 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1173224 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1173223 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1172767 | — | IC50 | > | 50000.0 | nM | - |