Assay Detail
ADMET
CHEMBL1177229
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Inhibition of human recombinant CYP24A1 expressed in chinese hamster V79 cells using [3H-1-beta]calcitriol after 60 mins by scintillation counting
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | V79 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CHEMBL4521) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and CYP24A1 inhibitory activity of N-(2-(1H-imidazol-1-yl)-2-phenylethyl)arylamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.24 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1171494 | — | — | 1 | 6.52 |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | 6.28 |
| CHEMBL1171662 | — | — | 1 | 5.55 |
| CHEMBL1171489 | — | — | 1 | 5.40 |
| CHEMBL1171660 | — | — | 1 | 5.19 |
| CHEMBL1171105 | — | — | 1 | 4.97 |
| CHEMBL1171106 | — | — | 1 | 4.64 |
| CHEMBL1171659 | — | — | 1 | 4.43 |
| CHEMBL1171107 | — | — | 1 | 4.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1171494 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL1171662 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL1171489 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1171660 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL1171105 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL1171106 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL1171659 | — | IC50 | = | 36900.0 | nM | 4.43 |
| CHEMBL1171107 | — | IC50 | = | 72000.0 | nM | 4.14 |