Assay Detail
Functional
CHEMBL1177258
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human PPARgamma-LBD expressed in COS7 cells co-transfected with Gal4 by luciferase based transactivation assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis, and biological evaluation of a novel class of gamma-secretase modulators with PPARgamma activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 5.10 | 5.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL518507 | — | — | 1 | 5.43 |
| CHEMBL1172001 | — | — | 1 | 5.37 |
| CHEMBL1173499 | — | — | 1 | 5.21 |
| CHEMBL1171834 | — | — | 1 | 5.18 |
| CHEMBL1171831 | — | — | 1 | 5.16 |
| CHEMBL1173376 | — | — | 1 | 5.12 |
| CHEMBL461883 | — | — | 1 | 5.08 |
| CHEMBL1172003 | — | — | 1 | 5.06 |
| CHEMBL1172019 | — | — | 1 | 5.05 |
| CHEMBL1172016 | — | — | 1 | 5.00 |
| CHEMBL1170852 | — | — | 1 | 4.99 |
| CHEMBL1170076 | — | — | 1 | 4.98 |
| CHEMBL1170264 | — | — | 1 | 4.96 |
| CHEMBL1172002 | — | — | 1 | 4.96 |
| CHEMBL1172000 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL518507 | — | EC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL1172001 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL1173499 | — | EC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL1171834 | — | EC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL1171831 | — | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL1173376 | — | EC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL461883 | — | EC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL1172003 | — | EC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL1172019 | — | EC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL1172016 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1170852 | — | EC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL1170076 | — | EC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL1170264 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL1172002 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL1172000 | — | EC50 | = | 12100.0 | nM | 4.92 |