Assay Detail
Binding
CHEMBL1177264
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Modulation of gamma-secretase-mediated cleavage of human APP expressed in CHO cells with human presenilin-1 assessed as activation of amyloid beta38 production after 24 hrs by ELISA
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of a novel class of gamma-secretase modulators with PPARgamma activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 22 | 5.00 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1170264 | — | — | 1 | 5.75 |
| CHEMBL1171833 | — | — | 1 | 5.72 |
| CHEMBL1171834 | — | — | 1 | 5.34 |
| CHEMBL1170852 | — | — | 1 | 5.26 |
| CHEMBL1173121 | — | — | 1 | 5.21 |
| CHEMBL1173376 | — | — | 1 | 5.19 |
| CHEMBL1173564 | — | — | 1 | 5.08 |
| CHEMBL1172000 | — | — | 1 | 5.05 |
| CHEMBL1172002 | — | — | 1 | 4.96 |
| CHEMBL461883 | — | — | 1 | 4.95 |
| CHEMBL1171851 | — | — | 1 | 4.89 |
| CHEMBL1170076 | — | — | 1 | 4.87 |
| CHEMBL1172016 | — | — | 1 | 4.79 |
| CHEMBL1172019 | — | — | 1 | 4.79 |
| CHEMBL1171832 | — | — | 1 | 4.76 |
| CHEMBL1172222 | — | — | 1 | 4.62 |
| CHEMBL1172003 | — | — | 1 | 4.62 |
| CHEMBL1172001 | — | — | 1 | 4.62 |
| CHEMBL1173499 | — | — | 1 | 4.51 |
| CHEMBL1171652 | — | — | 1 | - |
| CHEMBL1171831 | — | — | 1 | - |
| CHEMBL518507 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1170264 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1171833 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1171834 | — | EC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL1170852 | — | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL1173121 | — | EC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL1173376 | — | EC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL1173564 | — | EC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL1172000 | — | EC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL1172002 | — | EC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL461883 | — | EC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL1171851 | — | EC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL1170076 | — | EC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL1172016 | — | EC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL1172019 | — | EC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL1171832 | — | EC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL1172222 | — | EC50 | = | 24200.0 | nM | 4.62 |
| CHEMBL1172003 | — | EC50 | = | 24200.0 | nM | 4.62 |
| CHEMBL1172001 | — | EC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL1173499 | — | EC50 | = | 31100.0 | nM | 4.51 |
| CHEMBL1171652 | — | EC50 | - | — | - | |
| CHEMBL1171831 | — | EC50 | - | — | - | |
| CHEMBL518507 | — | EC50 | > | 40000.0 | nM | - |