Assay Detail
Binding
CHEMBL1177348
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Inhibition of His-tagged recombinant NS5B Cdelta 21 polymerase expressed in Escherichia coli DH5alpha by standard primer dependent elongation assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-based virtual screening, synthesis and SAR of novel inhibitors of hepatitis C virus NS5B polymerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 4.72 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL202580 | — | — | 1 | 6.70 |
| CHEMBL232875 | VALEANT | -1.0 | 1 | 5.52 |
| CHEMBL1172417 | — | — | 1 | 5.11 |
| CHEMBL1172416 | — | — | 1 | 5.08 |
| CHEMBL1173104 | — | — | 1 | 4.97 |
| CHEMBL1173103 | — | — | 1 | 4.88 |
| CHEMBL1173317 | — | — | 1 | 4.85 |
| CHEMBL1173020 | — | — | 1 | 4.79 |
| CHEMBL1173345 | — | — | 1 | 4.79 |
| CHEMBL1173791 | — | — | 1 | 4.77 |
| CHEMBL1173254 | — | — | 1 | 4.75 |
| CHEMBL1173418 | — | — | 1 | 4.74 |
| CHEMBL1173102 | — | — | 1 | 4.72 |
| CHEMBL1173255 | — | — | 1 | 4.70 |
| CHEMBL1172194 | — | — | 1 | 4.70 |
| CHEMBL1173346 | — | — | 1 | 4.66 |
| CHEMBL1172914 | — | — | 1 | 4.63 |
| CHEMBL1173040 | — | — | 1 | 4.55 |
| CHEMBL1173041 | — | — | 1 | 4.54 |
| CHEMBL1173793 | — | — | 1 | 4.44 |
| CHEMBL1173347 | — | — | 1 | 4.38 |
| CHEMBL1173792 | — | — | 1 | 4.37 |
| CHEMBL1173253 | — | — | 1 | 4.29 |
| CHEMBL1172821 | — | — | 1 | 4.26 |
| CHEMBL1172385 | — | — | 1 | 4.24 |
| CHEMBL1172822 | — | — | 1 | 4.22 |
| CHEMBL1173021 | — | — | 1 | 4.21 |
| CHEMBL1173790 | — | — | 1 | 4.17 |
| CHEMBL1172752 | — | — | 1 | - |
| CHEMBL1172820 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL202580 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL232875 | VALEANT | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1172417 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL1172416 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL1173104 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL1173103 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL1173317 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL1173020 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL1173345 | — | IC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL1173791 | — | IC50 | = | 16900.0 | nM | 4.77 |
| CHEMBL1173254 | — | IC50 | = | 17900.0 | nM | 4.75 |
| CHEMBL1173418 | — | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL1173102 | — | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL1173255 | — | IC50 | = | 19900.0 | nM | 4.70 |
| CHEMBL1172194 | — | IC50 | = | 20200.0 | nM | 4.70 |
| CHEMBL1173346 | — | IC50 | = | 21900.0 | nM | 4.66 |
| CHEMBL1172914 | — | IC50 | = | 23500.0 | nM | 4.63 |
| CHEMBL1173040 | — | IC50 | = | 28200.0 | nM | 4.55 |
| CHEMBL1173041 | — | IC50 | = | 29200.0 | nM | 4.54 |
| CHEMBL1173793 | — | IC50 | = | 36100.0 | nM | 4.44 |
| CHEMBL1173347 | — | IC50 | = | 42100.0 | nM | 4.38 |
| CHEMBL1173792 | — | IC50 | = | 42900.0 | nM | 4.37 |
| CHEMBL1173253 | — | IC50 | = | 50900.0 | nM | 4.29 |
| CHEMBL1172821 | — | IC50 | = | 55200.0 | nM | 4.26 |
| CHEMBL1172385 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL1172822 | — | IC50 | = | 60200.0 | nM | 4.22 |
| CHEMBL1173021 | — | IC50 | = | 61400.0 | nM | 4.21 |
| CHEMBL1173790 | — | IC50 | = | 68100.0 | nM | 4.17 |
| CHEMBL1172752 | — | IC50 | = | 200000.0 | nM | - |
| CHEMBL1172820 | — | IC50 | = | 250000.0 | nM | - |