Assay Detail
Binding
CHEMBL1177459
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Inhibition of human recombinant carbonic anhydrase 12 catalytic domain preincubated for 15 mins by CO2 hydration method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Coumarinyl-substituted sulfonamides strongly inhibit several human carbonic anhydrase isoforms: solution and crystallographic investigations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.55 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.60 |
| CHEMBL489182 | — | — | 1 | 8.22 |
| CHEMBL492022 | — | — | 1 | 7.26 |
| CHEMBL477822 | — | — | 1 | 7.20 |
| CHEMBL478669 | — | — | 1 | 7.11 |
| CHEMBL514556 | — | — | 1 | 6.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL489182 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL492022 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL477822 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL478669 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL514556 | — | Ki | = | 128.0 | nM | 6.89 |