Assay Detail
Binding
CHEMBL1177489
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Displacement of [3H]histamine from human histamine H4 receptor expressed in CHO-K1 cells after 1 hr by liquid scintillation counting
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of N-aryl-piperidine derivatives as potent (partial) agonists for human histamine H3 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.20 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1098230 | — | — | 1 | 8.96 |
| CHEMBL18661 | IMMEPIP | — | 1 | 7.66 |
| CHEMBL1172754 | — | — | 1 | 6.67 |
| CHEMBL1172775 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1098230 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL18661 | IMMEPIP | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL1172754 | — | Ki | = | 216.0 | nM | 6.67 |
| CHEMBL1172775 | — | Ki | = | 3100.0 | nM | 5.51 |