Assay Detail
Functional
CHEMBL1177568
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Antioxidant activity against AAPH-induced peroxyl radicals assessed as trolox equivalents measured for 80 mins by ORAC-FL method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.49 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3215816 | — | — | 1 | 8.59 |
| CHEMBL310555 | OXYQUINOLINE | -1.0 | 1 | 8.54 |
| CHEMBL3215602 | — | — | 1 | 8.48 |
| CHEMBL3216469 | — | — | 1 | 8.33 |
| CHEMBL95 | TACRINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3215816 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL310555 | OXYQUINOLINE | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL3215602 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL3216469 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL95 | TACRINE | IC50 | < | 0.01 | nM | - |