Assay Detail
Binding
CHEMBL1177586
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Inhibition of human CYP11B2 expressed in hamster V79MZh cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | V79MZh |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Isopropylidene substitution increases activity and selectivity of biphenylmethylene 4-pyridine type CYP17 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.99 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | 7.17 |
| CHEMBL1173260 | — | — | 1 | 6.96 |
| CHEMBL1172882 | — | — | 1 | 6.58 |
| CHEMBL1173327 | — | — | 1 | 6.43 |
| CHEMBL1171987 | — | — | 1 | 6.04 |
| CHEMBL1172779 | — | — | 1 | 6.02 |
| CHEMBL1172847 | — | — | 1 | 6.01 |
| CHEMBL1171991 | — | — | 1 | 5.95 |
| CHEMBL254328 | ABIRATERONE | 3.0 | 1 | 5.76 |
| CHEMBL1173335 | — | — | 1 | 5.73 |
| CHEMBL1173259 | — | — | 1 | 5.46 |
| CHEMBL1173326 | — | — | 1 | 5.42 |
| CHEMBL1172842 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL1173260 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1172882 | — | IC50 | = | 261.0 | nM | 6.58 |
| CHEMBL1173327 | — | IC50 | = | 368.0 | nM | 6.43 |
| CHEMBL1171987 | — | IC50 | = | 921.0 | nM | 6.04 |
| CHEMBL1172779 | — | IC50 | = | 948.0 | nM | 6.02 |
| CHEMBL1172847 | — | IC50 | = | 974.0 | nM | 6.01 |
| CHEMBL1171991 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL254328 | ABIRATERONE | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL1173335 | — | IC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL1173259 | — | IC50 | = | 3450.0 | nM | 5.46 |
| CHEMBL1173326 | — | IC50 | = | 3830.0 | nM | 5.42 |
| CHEMBL1172842 | — | IC50 | = | 49500.0 | nM | 4.30 |