Assay Detail
Binding
CHEMBL1211287
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Inhibition of HIV-1 integrase
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
CoMFA and CoMSIA 3D-QSAR studies on quionolone caroxylic acid derivatives inhibitors of HIV-1 integrase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 48 | 7.27 | 8.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL561619 | — | — | 1 | 8.25 |
| CHEMBL550220 | — | — | 1 | 8.24 |
| CHEMBL550080 | — | — | 1 | 8.24 |
| CHEMBL565125 | — | — | 1 | 8.22 |
| CHEMBL560836 | — | — | 1 | 8.17 |
| CHEMBL204656 | ELVITEGRAVIR | 4.0 | 1 | 8.14 |
| CHEMBL206604 | — | — | 1 | 8.09 |
| CHEMBL563677 | — | — | 1 | 8.09 |
| CHEMBL549816 | — | — | 1 | 8.05 |
| CHEMBL203443 | — | — | 1 | 8.05 |
| CHEMBL557891 | — | — | 1 | 8.01 |
| CHEMBL549549 | — | — | 1 | 7.92 |
| CHEMBL408699 | — | — | 1 | 7.84 |
| CHEMBL563525 | — | — | 1 | 7.83 |
| CHEMBL550893 | — | — | 1 | 7.68 |
| CHEMBL379664 | — | — | 1 | 7.62 |
| CHEMBL549546 | — | — | 1 | 7.60 |
| CHEMBL562360 | — | — | 1 | 7.59 |
| CHEMBL561099 | — | — | 1 | 7.51 |
| CHEMBL558481 | — | — | 1 | 7.50 |
| CHEMBL560439 | — | — | 1 | 7.47 |
| CHEMBL563162 | — | — | 1 | 7.46 |
| CHEMBL561100 | — | — | 1 | 7.42 |
| CHEMBL554722 | — | — | 1 | 7.42 |
| CHEMBL549611 | — | — | 1 | 7.39 |
| CHEMBL559903 | — | — | 1 | 7.37 |
| CHEMBL550895 | — | — | 1 | 7.36 |
| CHEMBL242883 | — | — | 1 | 7.30 |
| CHEMBL549750 | — | — | 1 | 7.30 |
| CHEMBL551437 | — | — | 1 | 7.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL561619 | — | IC50 | = | 5.623 | nM | 8.25 |
| CHEMBL550220 | — | IC50 | = | 5.754 | nM | 8.24 |
| CHEMBL550080 | — | IC50 | = | 5.754 | nM | 8.24 |
| CHEMBL565125 | — | IC50 | = | 6.026 | nM | 8.22 |
| CHEMBL560836 | — | IC50 | = | 6.761 | nM | 8.17 |
| CHEMBL204656 | ELVITEGRAVIR | IC50 | = | 7.244 | nM | 8.14 |
| CHEMBL206604 | — | IC50 | = | 8.128 | nM | 8.09 |
| CHEMBL563677 | — | IC50 | = | 8.128 | nM | 8.09 |
| CHEMBL549816 | — | IC50 | = | 8.913 | nM | 8.05 |
| CHEMBL203443 | — | IC50 | = | 8.913 | nM | 8.05 |
| CHEMBL557891 | — | IC50 | = | 9.772 | nM | 8.01 |
| CHEMBL549549 | — | IC50 | = | 12.02 | nM | 7.92 |
| CHEMBL408699 | — | IC50 | = | 14.45 | nM | 7.84 |
| CHEMBL563525 | — | IC50 | = | 14.79 | nM | 7.83 |
| CHEMBL550893 | — | IC50 | = | 20.89 | nM | 7.68 |
| CHEMBL379664 | — | IC50 | = | 23.99 | nM | 7.62 |
| CHEMBL549546 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL562360 | — | IC50 | = | 25.7 | nM | 7.59 |
| CHEMBL561099 | — | IC50 | = | 30.9 | nM | 7.51 |
| CHEMBL558481 | — | IC50 | = | 31.62 | nM | 7.50 |
| CHEMBL560439 | — | IC50 | = | 33.88 | nM | 7.47 |
| CHEMBL563162 | — | IC50 | = | 34.67 | nM | 7.46 |
| CHEMBL561100 | — | IC50 | = | 38.02 | nM | 7.42 |
| CHEMBL554722 | — | IC50 | = | 38.02 | nM | 7.42 |
| CHEMBL549611 | — | IC50 | = | 40.74 | nM | 7.39 |
| CHEMBL559903 | — | IC50 | = | 42.66 | nM | 7.37 |
| CHEMBL550895 | — | IC50 | = | 43.65 | nM | 7.36 |
| CHEMBL242883 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL549750 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL551437 | — | IC50 | = | 54.95 | nM | 7.26 |
| CHEMBL561827 | — | IC50 | = | 64.57 | nM | 7.19 |
| CHEMBL560234 | — | IC50 | = | 69.18 | nM | 7.16 |
| CHEMBL558286 | — | IC50 | = | 77.62 | nM | 7.11 |
| CHEMBL558287 | — | IC50 | = | 83.18 | nM | 7.08 |
| CHEMBL550691 | — | IC50 | = | 83.18 | nM | 7.08 |
| CHEMBL551235 | — | IC50 | = | 114.82 | nM | 6.94 |
| CHEMBL561437 | — | IC50 | = | 213.8 | nM | 6.67 |
| CHEMBL549405 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL559705 | — | IC50 | = | 371.54 | nM | 6.43 |
| CHEMBL559704 | — | IC50 | = | 407.38 | nM | 6.39 |
| CHEMBL561423 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL554504 | — | IC50 | = | 676.08 | nM | 6.17 |
| CHEMBL549338 | — | IC50 | = | 724.44 | nM | 6.14 |
| CHEMBL560960 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL560761 | — | IC50 | = | 1071.52 | nM | 5.97 |
| CHEMBL549404 | — | IC50 | = | 1174.9 | nM | 5.93 |
| CHEMBL382680 | — | IC50 | = | 1621.81 | nM | 5.79 |
| CHEMBL557480 | — | IC50 | = | 2290.87 | nM | 5.64 |