Assay Detail
Functional
CHEMBL1211328
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Antagonist activity at human recombinant NPS receptor expressed in CHOK1 cells assessed as inhibition of NPS-induced calcium mobilization by FLIPR assay
14
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of a new series of Neuropeptide S receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.10 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1210244 | — | — | 1 | 8.15 |
| CHEMBL1210313 | — | — | 3 | 8.00 |
| CHEMBL1210311 | — | — | 1 | 7.85 |
| CHEMBL1210177 | — | — | 1 | 7.75 |
| CHEMBL1210312 | — | — | 1 | 7.66 |
| CHEMBL1210242 | — | — | 1 | 7.51 |
| CHEMBL1210411 | — | — | 1 | 6.99 |
| CHEMBL1210243 | — | — | 1 | 6.84 |
| CHEMBL1210241 | — | — | 1 | 6.49 |
| CHEMBL1210412 | — | — | 1 | 6.40 |
| CHEMBL1210179 | — | — | 1 | 6.14 |
| CHEMBL1210178 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1210244 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1210313 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1210311 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1210177 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1210312 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1210313 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1210242 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL1210411 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL1210243 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL1210241 | — | IC50 | = | 326.0 | nM | 6.49 |
| CHEMBL1210412 | — | IC50 | = | 398.0 | nM | 6.40 |
| CHEMBL1210179 | — | IC50 | = | 725.0 | nM | 6.14 |
| CHEMBL1210313 | — | IC50 | = | 785.0 | nM | 6.11 |
| CHEMBL1210178 | — | IC50 | = | 1577.0 | nM | 5.80 |