Assay Detail
Functional
CHEMBL1211418
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Antiproliferative activity against human K562 cells after 48 hrs
54
Total Activities
54
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, antiproliferative activity and inhibition of tubulin polymerization by 1,5- and 1,8-disubstituted 10H-anthracen-9-ones bearing a 10-benzylidene or 10-(2-oxo-2-phenylethylidene) moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 54 | 6.04 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL378544 | VINBLASTINE SULFATE | 4.0 | 1 | 9.00 |
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | 4.0 | 1 | 8.00 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.70 |
| CHEMBL1210959 | — | — | 1 | 7.00 |
| CHEMBL1209943 | — | — | 1 | 6.68 |
| CHEMBL1210319 | — | — | 1 | 6.66 |
| CHEMBL1210322 | — | — | 1 | 6.64 |
| CHEMBL1210321 | — | — | 1 | 6.62 |
| CHEMBL1210876 | — | — | 1 | 6.60 |
| CHEMBL1210320 | — | — | 1 | 6.60 |
| CHEMBL1209944 | — | — | 1 | 6.57 |
| CHEMBL1210253 | — | — | 1 | 6.54 |
| CHEMBL1210879 | — | — | 1 | 6.30 |
| CHEMBL1210818 | — | — | 1 | 6.21 |
| CHEMBL1210420 | — | — | 1 | 6.14 |
| CHEMBL1210419 | — | — | 1 | 6.03 |
| CHEMBL1210963 | — | — | 1 | 5.89 |
| CHEMBL1210067 | — | — | 1 | 5.85 |
| CHEMBL1210962 | — | — | 1 | 5.85 |
| CHEMBL1210066 | — | — | 1 | 5.82 |
| CHEMBL1210323 | — | — | 1 | 5.80 |
| CHEMBL1210184 | — | — | 1 | 5.80 |
| CHEMBL1210416 | — | — | 1 | 5.77 |
| CHEMBL129938 | — | — | 1 | 5.77 |
| CHEMBL337845 | — | — | 1 | 5.77 |
| CHEMBL1210417 | — | — | 1 | 5.72 |
| CHEMBL130441 | — | — | 1 | 5.70 |
| CHEMBL335282 | — | — | 1 | 5.70 |
| CHEMBL131667 | — | — | 1 | 5.70 |
| CHEMBL1210880 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL378544 | VINBLASTINE SULFATE | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL107 | COLCHICINE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1210959 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1209943 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL1210319 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1210322 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1210321 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL1210876 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL1210320 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL1209944 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL1210253 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1210879 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1210818 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL1210420 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL1210419 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL1210963 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1210067 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL1210962 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1210066 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1210323 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1210184 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1210416 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL129938 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL337845 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1210417 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL335282 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL131667 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1210880 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL130441 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL338715 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL129939 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL130560 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL1210418 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL1210877 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1210878 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1210250 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL1210819 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1210186 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL1209942 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL1209941 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL1210252 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL1210065 | — | IC50 | - | — | - | |
| CHEMBL1210960 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1210961 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL61 | PODOFILOX | IC50 | - | — | - | |
| CHEMBL1210251 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL1210249 | — | IC50 | - | — | - | |
| CHEMBL1210188 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL1210187 | — | IC50 | > | 15000.0 | nM | - |