Assay Detail
Binding
CHEMBL1211490
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]CP55490 from human recombinant cannabinoid CB1 receptor expressed in CHO cells
10
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and cannabinoid-1 receptor binding affinity of conformationally constrained analogs of taranabant.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.36 | 9.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL373626 | — | — | 1 | 9.27 |
| CHEMBL1209596 | — | — | 1 | 9.23 |
| CHEMBL220360 | TARANABANT | 3.0 | 1 | 9.13 |
| CHEMBL1209597 | — | — | 1 | 7.66 |
| CHEMBL1209668 | — | — | 2 | 7.60 |
| CHEMBL1209598 | — | — | 1 | 6.47 |
| CHEMBL1209670 | — | — | 1 | 6.09 |
| CHEMBL1209669 | — | — | 1 | 5.89 |
| CHEMBL1209749 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL373626 | — | IC50 | = | 0.54 | nM | 9.27 |
| CHEMBL1209596 | — | IC50 | = | 0.59 | nM | 9.23 |
| CHEMBL220360 | TARANABANT | IC50 | = | 0.74 | nM | 9.13 |
| CHEMBL1209597 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1209668 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1209668 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1209598 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL1209670 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL1209669 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1209749 | — | IC50 | = | 2000.0 | nM | 5.70 |